I skipped the first part since I've rarely attended the lectures. :D But the first part is about carbohydrate metabolism. Maybe I'll post the summary later.
Okay then...
Let's go on to the first lecture of second part of LSM2101: Overview
1. Why do we need amino acids?
protein synthesis, energy & gluconeogenic substrates, neurotransmitter, hormones, heme & nucleotide biosynthesis.
2. Composition of body
50% dry matter = protein, 1-2% dry matter = free amino acids, no large reservoir of amino acids.
3. Where does body gets amino acids?
dietary proteins (exogenous), breakdown of body's proteins (endogenous), biosynthesis.
4. Dietary Proteins' Fate
- Intake:
- minimum daily req = 30 g for 70kg person
- Digestion:
- Absorption & Transportation:
- Inborn Errors: Aminoacidurias
- Cystinuria: failure to absorp CystineOrnithineArginineLysine -> Cystine Kidney Stones
- Hartnup's Disease: failure to absorp Trp, Phe, neutral AA -> Cerebellar ataxia (coordination of involuntary movement), Pellagra-like symptoms.
- Balance: Intake = Output
- Positive N Balance: Intake > Output (Growth, Pregnancy, Refeeding)
- Negative N Balance: Intake < Output (Starvation, Senescence, Metabolic Stress)
